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These medications reduce hyperglycemia (Hb1Ac reduction of 0.8 1.4%) through the inhibition of glucose reabsorption in the proximal convoluted tubule of the kidney and the resulting increase in glycosuria ( In light of this evidence, these therapies have opened a new paradigm not only for the management of altered glucose metabolism in T2D but also in consideration of their pleiotropic effects ( Emerging data indicate that the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis may play a role in either mediating the metabolic and neuroendocrine effect of these drugs or responding to the profound body modifications fostered by GLP-1RAs and SGLT-2is

Consistent meal timing, protein intake above 100 grams daily, and 150+ minutes of weekly movement accelerate results by 30-50% compared to medication alone

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Since melanin is a protective pigment in skin, it blocks UV rays from damaging DNA, and protects against skin cancer